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Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Flavio Martinez-Morales1, Enrique Maldonado-Cervantes2, Mario Alberto Isiordia-Espinoza3 and Othoniel Hugo Aragon-Martinez1,*

1Department of Pharmacology, School of Medicine, University of San Luis Potosi, San Luis Potosi, S.L.P., Mexico
2Multidisciplinary Academic Unit Middle Zone, University of San Luis Potosi, Rioverde, S.L.P., Mexico
3Department of Pharmacology, School of Odontology, University of Baja California, Mexicali, Baja California, Mexico

Corresponding Author Email: hugo.aragon@uaslp.mx (Othoniel Hugo Aragon-Martinez)

Page No: 298 - 306

Keywords: Aspartame, Coconut fat, Cardiovascular factors, Body weight and Blood pressure

Received - April 13, 2015; Revision - May 11, 2015; Accepted - June 25, 2015 Available Online - June 26, 2015

doi: http://dx.doi.org/10.18006/2015.3(3).298.306


The present study evaluates the effect of aspartame intake in rats under a diet mimicking the trends of fat consumption in the society. The composition of the experimental diet was within the recommended human limits except the saturated fat amount supplying from coconut fat. Rats under the experimental diet showed an increase in the body weight, transitory increase in the blood pressure and in plasma values of glucose and triglycerides alongside a transitory reduction in plasma urea versus the standard group. Rats under the experimental diet plus aspartame intake (54.8 ± 7.3 mg/kg bw/day) did not show any increase of body weight and in plasma values of glucose and triglycerides while showed an improvement in the plasma value of urea with respect the group under only the experimental diet. However, the aspartame group showed a more maintained increase of blood pressure. In conclusion, experimental diet produces negative effects on cardiovascular risk factors of the rats while the aspartame intake under the experimental feeding had mixed effects on the cardiometabolic factors of the animals.

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